Rheumatoid arthritis symptoms are a chronic inflammatory disorder that can affect more than just your joints. In some people, the condition can damage various body systems, including the skin, eyes, lungs, heart, and blood vessels.
An autoimmune disorder, rheumatoid arthritis occurs when your immune system mistakenly attacks your own body’s tissues.
Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of your joints, causing a painful swelling that can eventually result in bone erosion and joint deformity.
The inflammation associated with rheumatoid arthritis is what can damage other parts of the body as well. While new types of medications have improved treatment options dramatically, severe rheumatoid arthritis can still cause physical disabilities.
Rheumatoid arthritis Symptoms
Signs and rheumatoid arthritis symptoms of rheumatoid arthritis symptoms may include:
- Tender, warm, swollen joints
- Joint stiffness that is usually worse in the mornings and after inactivity
- Fatigue, fever, and loss of appetite
Early rheumatoid arthritis tends to affect your smaller joints first — particularly the joints that attach your fingers to your hands and your toes to your feet.
As the disease progresses, symptoms often spread to the wrists, knees, ankles, elbows, hips, and shoulders. In most cases, rheumatoid arthritis symptoms occur in the same joints on both sides of your body.
About 40% of people who have rheumatoid arthritis also experience signs and rheumatoid arthritis symptoms that don’t involve the joints. Areas that may be affected include:
- Skin
- Eyes
- Lungs
- Heart
- Kidneys
- Salivary glands
- Nerve tissue
- Bone marrow
- Blood vessels
Rheumatoid arthritis signs and rheumatoid arthritis symptoms may vary in severity and may even come and go. Periods of increased disease activity, called flares, alternate with periods of relative remission — when the swelling and pain fade or disappear. Over time, rheumatoid arthritis can cause joints to deform and shift out of place.
When to see a doctor
Make an appointment with your doctor if you have persistent joint discomfort and swelling.
Causes for rheumatoid arthritis
Rheumatoid arthritis is an autoimmune disease. Normally, your immune system helps protect your body from infection and disease. In rheumatoid arthritis, your immune system attacks healthy tissue in your joints. It can also cause medical problems with your heart, lungs, nerves, eyes, and skin.
Doctors don’t know what starts this process, although a genetic component appears likely. While your genes don’t cause rheumatoid arthritis, they can make you more likely to react to environmental factors — such as infection with certain viruses and bacteria — that may trigger the disease.
Risk factors for rheumatoid arthritis
Factors that may increase your risk of rheumatoid arthritis include:
- Your sex: Women are more likely than men to develop rheumatoid arthritis.
- Age: Rheumatoid arthritis can occur at any age, but it most commonly begins in middle age.
- Family history: If a member of your family has rheumatoid arthritis, you may have an increased risk of the disease.
- Smoking: Cigarette smoking increases your risk of developing rheumatoid arthritis, particularly if you have a genetic predisposition for developing the disease. Smoking also appears to be associated with greater disease severity.
- Excess weight: People who are overweight appear to be at a somewhat higher risk of developing rheumatoid arthritis.
Complications Rheumatoid arthritis
Rheumatoid arthritis increases your risk of developing:
- Osteoporosis: Rheumatoid arthritis itself, along with some medications used for treating rheumatoid arthritis, can increase your risk of osteoporosis — a condition that weakens your bones and makes them more prone to fracture.
- Rheumatoid nodules: These firm bumps of tissue most commonly form around pressure points, such as the elbows. However, these nodules can form anywhere in the body, including the heart and lungs.
- Dry eyes and mouth: People who have rheumatoid arthritis are much more likely to develop Sjogren’s syndrome, a disorder that decreases the amount of moisture in the eyes and mouth.
- Infections: Rheumatoid arthritis itself and many of the medications used to combat it can impair the immune system, leading to increased infections. Protect yourself with vaccinations to prevent diseases such as influenza, pneumonia, shingles, and COVID-19.
- Abnormal body composition: The proportion of fat to lean mass is often higher in people who have rheumatoid arthritis symptoms, even in those who have a normal body mass index (BMI).
- Carpal tunnel syndrome: If rheumatoid arthritis affects your wrists, the inflammation can compress the nerve that serves most of your hands and fingers.
- Heart problems: Rheumatoid arthritis can increase your risk of hardened and blocked arteries, as well as inflammation of the sac that encloses your heart.
- Lung disease: People with rheumatoid arthritis have an increased risk of inflammation and scarring of the lung tissues, which can lead to progressive shortness of breath.
- Lymphoma: Rheumatoid arthritis increases the risk of lymphoma, a group of blood cancers that develop in the lymph system.
Diagnosis of rheumatoid arthritis
Diagnosis of rheumatoid arthritis usually begins with a physical examination. The doctor asks questions about signs and symptoms and examines the affected joints. In addition, the doctor may advise the following:
Testing the rate of erythrocyte sedimentation
In people who suffer from rheumatoid arthritis symptoms, the erythrocyte sedimentation rate (ESR) test, which measures the speed at which red blood cells settle in a sample of non-clotted blood, usually shows a high percentage that indicates the presence of inflammation in the body.
Other common blood tests
Check for the presence of antibodies that cause rheumatism, i.e. rheumatoid factor (RF – Rheumatoid factor) and anti-cyclic citrullinated peptide – anti – CCP) in the blood.
In general, rheumatoid factors and anti-cyclic citrullinated peptide antibodies can be found in the blood of patients with rheumatoid arthritis, but not in all cases.
In the early stages of rheumatoid arthritis symptoms, the presence of these antibodies in the blood may be an indicator of an increased risk of joint damage, and they may also be found in people with chronic infections such as active tuberculosis, autoimmune rheumatic disease, lupus, and Sjögren’s syndrome.
Other tests
Includes the following:
- Examination of fluids in the joint.
- X-ray imaging.
